PUBLICATIONS

Kuniaki SAITO Ph.D.

  • Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K. Piwi modulates chromatin accessibility by regulating multiple factors including histone H1 to represss transposons. Molecular Cell 63: 408-419 (2016)
  • Ohtani H, Iwasaki YW, Shibuya A, Siomi H, Siomi MC, Saito K. DmGTSF1 is necessary for Piwi–piRISC-mediated transcriptional transposon silencing in Drosophila. Genes Dev 27: 1656-1661 (2013)
  • Saito K, Inagaki S, Mituyama T, Kawamura Y, Ono Y, Sakota E, Kotani H, Asai K, Siomi H, Siomi MC. A regulatory circuit for piwi by traffic jam, a large Maf, in Drosophila gonadal somas. Nature 461: 1296-1299 (2009)
  • Kawamura Y#, Saito K# (#co-first authors), Kin T, Ono Y, Asai K, Sunohara T, Okada TN, Siomi MC, Siomi H. Drosophila endogenous small RNAs bind to Argonaute2 in somatic cells. Nature 453: 793-797 (2008)
  • Gunawardane LS#, Saito K# (#co-first authors), Nishida KM#, Miyoshi K, Kawamura Y, Nagami T, Siomi H, Siomi MC. A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science 315: 1587-1590 (2007)
  • Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K. Piwi modulates chromatin accessibility by regulating multiple factors including histone H1 to represss transposons. Molecular Cell (2016)
  • Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, *Agata K. Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian. Developmental Cell 37: 226-237 (2016)
  • Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, and Siomi MC. Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. Cell Reports 8: 103-113 (2014)
  • Hirano T, Iwasaki YW, Lin ZY, Imamura M, Seki NM, Sasaki E, Saito K, Okano H, Siomi MC, and Siomi H. Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA 20: 1223-1237 (2014)
  • Ohtani H, Iwasaki YW, Shibuya A, Siomi H, Siomi MC, Saito K. DmGTSF1 is necessary for Piwi–piRISC-mediated transcriptional transposon silencing in Drosophila. Genes Dev 27: 1656-1661 (2013)
  • Nishimasu K, Ishizu H, Saito K, Fukuhara S, Kamatani MK, Bonnefond L, Matsumoto N, Nishizawa, T, Nakanaga K, Aoki J, Ishitani R, Siomi H, Siomi MC, and Nureki O. Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature 491: 284-287 (2012)
  • Fujiwara Y#, Kasashima K#, Saito K# (#co-first authors), Fukuda M, Fukao A, Sasano Y, Inoue K, Fujiwara T, Sakamoto H. Microtubule association of a neuronal RNA-binding protein HuD through its binding to the light chain of MAP1B. Biochimie 93: 1552-1561 (2011)
  • Saito K, Ishizu H, Komai M, Kotani H, Kawamura Y, Nishida KM, Siomi H, *Siomi MC. Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. Genes Dev 24: 2493-2498 (2010)
  • Inose H, Ochi H, Kimura A, Fujita K, Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto, S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K, and Takeda S. A microRNA regulatory mechanism of osteoblast differentiation. PNAS 106: 20794-20799 (2009)
  • Saito K, Inagaki S, Mituyama T, Kawamura Y, Ono Y, Sakota E, Kotani H, Asai K, Siomi H, Siomi MC. A regulatory circuit for piwi by traffic jam, a large Maf, in Drosophila gonadal somas. Nature 461: 1296-1299 (2009)
  • Hartig JV, Esslinger S, Bottcher R, Saito K, and *Forstemann K. Endo-siRNAs depend on a novel isoform of loquacious and target artificially introduced, high-copy sequences. EMBO J 28: 2932-2944 (2009)
  • Kawamura Y#, Saito K# (#co-first authors), Kin T, Ono Y, Asai K, Sunohara T, Okada TN, Siomi MC, Siomi H. Drosophila endogenous small RNAs bind to Argonaute2 in somatic cells. Nature 453: 793-797 (2008)
  • Saito K, Sakaguchi Y, Suzuki T, Suzuki T, Siomi H, *Siomi MC. Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev 21: 1603-1608 (2007)
  • Nishida KM, Saito K, Mori T, Kawamura Y, Nagami-Okada T, Inagaki S, Siomi H, *Siomi MC. Gene silencing mechanisms mediated by Aubergine-piRNA complexes in Drosophila male gonad. RNA 13: 1911-1922 (2007)
  • Gunawardane LS#, Saito K# (#co-first authors), Nishida KM#, Miyoshi K, Kawamura Y, Nagami T, Siomi H, Siomi MC. A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science 315: 1587-1590 (2007)
  • Saito K, Nishida KM, Mori T, Kawamura Y, Miyoshi K, Nagami T, Siomi H, Siomi MC. Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev 20: 2214-2222 (2006)
  • Saito K, Ishizuka A, Siomi H, Siomi MC. Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS Biol 3: e235 (2005)
  • Saito K, Fujiwara T, Katahira J, Inoue K, Sakamoto H. TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. Biochemical and Biophysical Research Communications 321: 291-297 (2004)
  • Kasashima K, Sakashita E, Saito K, Sakamoto H. Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins. Nucleic Acids Research 30: 4519-4526 (2002)
  • Saito K. The epigenetic regulation of transposable elements by PIWI-interacting RNAs in Drosophila. Genes & Genetic Systems 88: 9-17 (2013)
  • Saito K, and Siomi MC. Small RNA-mediated quiescence of transposable elements in Drosophila. Developmental Cell 19: 687-697 (2010)
  • Siomi MC, Saito K, Siomi H. How selfish retorotransposons are silenced in Drosophila germline and somatic cells. FEBS Letters 582: 2473-2478 (2008)
  • Saito K. RNAi and overexpression of genes in ovarian somatic cells. Methods in Molecular Biology 1093: 25-33 (2014)
  • Ishizuka A, Saito K, Siomi MC, Siomi H. In vitro precursor microRNA processing assays using Drosophila Schneider-2 cell lysate. Methods in Molecular Biology 342: 277-286 (2006)

Shu KONDO Ph.D.

  • Kondo S, Vedanayagam J, Mohammed J, Eizadshenass S, Kan L, Pang N, Aradhya R, Siepel A, Steinhauer J, Lai EC. New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes Dev 31(18): 1841-1846 (2017)
  • Lin CJ, Wen J, Bejarano F, Hu F, Bortolamiol-Becet D, Kan L, Sanfilippo P, Kondo S, Lai EC. Characterization of a TUTase/RNase complex required for Drosophila gametogenesis. RNA 23: 284-296 (2017)
  • Iatsenko I, Kondo S, Mengin-Lecreulx D, Lemaitre B. PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway. Immunity 45: 1013-1023 (2016)
  • Kondo S, Ueda R. Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics 195: 715-21 (2013)
  • Kondo S, Booker M, Perrimon N. Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics 183: 1165-73 (2009)
  • Kondo S, Vedanayagam J, Mohammed J, Eizadshenass S, Kan L, Pang N, Aradhya R, Siepel A, Steinhauer J, Lai EC. New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes Dev 31(18): 1841-1846 (2017)
  • Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. The m6A pathway facilitates sex determination in Drosophila. Nature Commun. 8: 15737 (2017)
  • Lin CJ, Wen J, Bejarano F, Hu F, Bortolamiol-Becet D, Kan L, Sanfilippo P, Kondo S, Lai EC. Characterization of a TUTase/RNase complex required for Drosophila gametogenesis. RNA 23: 284-296 (2017)
  • Yamagata N, Hiroi M, Kondo S, Abe A, Tanimoto H. Suppression of Dopamine Neurons Mediates Reward. PLoS Biol. 14: e1002586 (2016)
  • Iatsenko I, Kondo S, Mengin-Lecreulx D, Lemaitre B. PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway. Immunity 45: 1013-1023 (2016)
  • Chen J, Reiher W, Hermann-Luibl C, Sellami A, Cognigni P, Kondo S, Helfrich-Förster C, Veenstra JA, Wegener C. Allatostatin A Signalling regulates Feeding and Sleep and is modulated by PDF. PLoS Genet. 12: e1006346 (2016)
  • Yang L, Paul S, Trieu KG, Dent LG, Froldi F, Forés M, Webster K, Siegfried KR, Kondo S, Harvey K, Cheng L, Jiménez G, Shvartsman SY, Veraksa A. Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Proc. Natl. Acad. Sci. USA 113: 10583-10588 (2016)
  • Yoo SK, Pascoe HG, Pereira T, Kondo S, Jacinto A, Zhang X, Hariharan IK. Plexins function in epithelial repair in both Drosophila and zebrafish. Nat. Commun. 7: 12282 (2016)
  • Danielsen ET, Moeller ME, Yamanaka N, Ou Q, Laursen JM, Soenderholm C, Zhuo R, Phelps B, Tang K, Zeng J, Kondo S, Nielsen CH, Harvald EB, Faergeman NJ, Haley MJ, O'Connor KA, King-Jones K, O'Connor MB, Rewitz KF. A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing. Dev. Cell 37: 558-70 (2016)
  • Ito H, Sato K, Kondo S, Ueda R, Yamamoto D. Fruitless Represses robo1 Transcription to Shape Male-Specific Neural Morphology and Behavior in Drosophila. Curr. Biol. 26: 1532-42 (2016)
  • Poon CL, Mitchell KA, Kondo S, Cheng LY, Harvey KF. The Hippo Pathway Regulates Neuroblasts and Brain Size in Drosophila melanogaster. Curr. Biol. 26: 1034-42 (2016)
  • Zhai Z, Kondo S, Ha N, Boquete JP, Brunner M, Ueda R, Lemaitre B. Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nat. Commun. 6: 10219 (2015)
  • Dudzic JP, Kondo S, Ueda R, Bergman CM, Lemaitre B. Drosophila innate immunity: regional and functional specialization of prophenoloxidases. BMC Biol. 13: 81 (2015)
  • Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Xia W, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N. The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. Genetics 201: 843-52 (2015)
  • Ren GR, Hauser F, Rewitz KF, Kondo S, Engelbrecht AF, Didriksen AK, Schjøtt SR, Sembach FE, Li S, Søgaard KC, Søndergaard L, Grimmelikhuijzen CJ. CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila. PLoS One 10: e0133017 (2015)
  • Hentze JL, Carlsson MA, Kondo S, Nässel DR, Rewitz KF. The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila. Sci. Rep. 5: 11680 (2015)
  • Yamamoto-Hino M, Muraoka M, Kondo S, Ueda R, Okano H, Goto S. Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation. Proc. Natl. Acad. Sci. U. S. A. 112: 5809-14 (2015)
  • Kondo S, Ueda R. Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics 195: 715-21 (2013)
  • Suda T, Hama T, Kondo S, Yuza Y, Yoshikawa M, Urashima M, Kato T, Moriyama H. Copy number amplification of the PIK3CA gene is associated with poor prognosis in non-lymph node metastatic head and neck squamous cell carcinoma. BMC Cancer 12: 416 (2012)
  • Kondo S, Perrimon N. A genome-wide RNAi screen identifies core components of the G2-M DNA damage checkpoint. Sci. Signal. 4: rs1 (2011)
  • Hama T, Yuza Y, Saito Y, O-uchi J, Kondo S, Okabe M, Yamada H, Kato T, Moriyama H, Kurihara S, Urashima M. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist 14: 900-8 (2009)
  • Kondo S, Booker M, Perrimon N. Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics 183: 1165-73 (2009)
  • Williams, D.W., Kondo, S., Krzyzanowska, A., Hiromi, Y., Truman, J.W. Local caspase activity directs engulfment of dendrites during pruning. Nat. Neurosci. 9: 1234-6 (2006)
  • Kondo S, Senoo-Matsuda N, Hiromi Y, Miura M. DRONC coordinates cell death and compensatory proliferation. Mol. Cell. Biol. 26: 7258-68 (2006)
  • Kondo S, Kuwahara Y, Kondo M, Naruse K, Mitani H, Wakamatsu Y, Ozato K, Asakawa S, Shimizu N, Shima A. The medaka rs-3 locus required for scale development encodes ectodysplasin-A receptor. Curr. Biol. 11: 1202-1206 (2001)
  • Naruse K, Fukamachi S, Mitani H, Kondo M, Matsuoka T, Kondo S, Hanamura N, Morita Y, Hasegawa K, Nishigaki R, Shimada A, Wada H, Kusakabe T, Suzuki N, Kinoshita M, Kanamori A, Terado T, Kimura H, Nonaka M, Shima A. A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution. Genetics 154: 1773-1784 (2000)
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